Alzheimer s Disease ( Ad ) - 2192 Words

Alzheimer’s disease (AD) is a cognitive neurodegerative disorder and one of the major forms of dementia; it represents 60-80% of the dementia patients (Barker et at., 2002). It is estimated by the end of 2015, 53 million people of America would be affected and this would almost double by 2025 and triple by 2050, hence making research momentous for the cure (Hebert et al., 2013). It takes almost 8.5 years between the onset of symptoms of the disease and death (Francis, Palmer, Snape et al., 1998). AD affects the hippocampus and the neocortex region of the brain. These are affected by the deposition of amyloid ÃŽ ² in senile plaques, neurofibrilary tangles and the decline of neuronal synapses. The symptoms of AD includes memory loss resulting in disrupted daily life, confusion with place and time, problem with speaking and writing and many other. Earlier research was done on the inhibition of amyloid ÃŽ ², but a relatively new approach is to find inhibitors for acetlycholinesterases enzyme (AChE). The action of AChE results in the blockage of transmission of acetylcholine (ACh), hence hyperphosphorylating the tau protein which affects the breakage of amyloid precursor protein(APP), which firther results in the increase in amyloid ÃŽ ². The binding of AChE causes decrease in the binding of ACh to muscarinic recptor and nicotinic receptors (Francis, Palmer, Sna pe et al., 1998). A recent study has shown that ACh does not only have cognitive functions, it regulates theShow MoreRelatedAlzheimer s Disease ( Ad )1108 Words   |  5 Pages Alzheimer’s Disease (AD) is a form of dementia that affects 5 million people in the United States alone. One out of every three Seniors die of the disease just in the United States; 80 million suffering world wide making AD the 6th largest cause of death (climax) (Humpel 1; Alzheimer’s Association). AD is the most common dementia; affecting the neuroplasticity of the brain resulting in physical shrinking of the tissues; thus causing neurodegeneration. Diagnosis of the disease is complex, costlyRead MoreAlzheimer s Disease ( Ad ) Essay1112 Words   |  5 Pages Alzheimer disease (AD) is the most common cause of dementia in the elderly, accounting for 65–70% of all cases (Jellinger, Janetzky, Attems, Kienzl, 2008). The other dementias are of the Parkinson s group, the fronto-temporal gr oup and the vascular group. The total worldwide yearly costs for the treatment and care of patients suffering from dementia are estimated to be around 250 billion US dollars. The lifetime risk for AD between the ages of 65 and 100 is 33% for men and 45% for women withRead MoreAlzheimer s Disease ( Ad ) Essay1765 Words   |  8 PagesAlzheimer’s Disease is similar to a literal chipping block of the brain; it is like this conscious genetic machine that (figuratively and) continually deep-fries brain cells and makes them clump up into masses that entangle many cognitive processes that allow an individual to be who they are. It is the slow progression into death where the mental faculties are ravaged and pilfered; the sinews that tie each and every neuron and synapse together. Alzheimer’s disease (AD) is a condition where thereRead MoreAlzheimer s Disease ( Ad )1244 Words   |  5 PagesAlzheimer s disease(AD) wrecks memory and other essential mental capacities. Research has shown that numerous individuals with dementia, particularly those who are sixty-five or older, have brain impairments. All through the numerous periods of Alzheimer s disease, people appear to show any indication, yet harmful changes are occurring in the cerebrum. An unnatural deposit of proteins structure amyloid plaques and tau tangles all through the brain, and once the active neurons quit working, theyRead MoreAlzheimer s Disease ( Ad )1112 Words   |  5 PagesAlzheimer’s disease (AD) is a complex, multifactorial neurodegenerative disease that is currently being managed by symptomatic treatment. The affected areas include the central nervous system (CNS) which is made up of the brain and spinal cord. The brain is essential in managing our thoughts, cognitive abilities, and our ability to interact with the environment. AD patients are known to experience symptoms such as memory loss in the early stages which develop into speaking difficulties to eventuallyRead More Alzheimer s Disease ( Ad )1068 Words   |  5 PagesAlzheimer’s disease (AD) is a neurodegenerative disorder characterized by ÃŽ ²-amyloid plaque formation caused by aggregation of ÃŽ ²-amyloid42 within the brain leading to a progressive decline in cognitive function and memory loss (2). Hyperphosphorylated tau protein is occasionally found in brains of AD patients with advanced pathology however, it is not necessarily an indicator of AD but considered a sign of disease severity (2, 4, Kosik et al, 1986). AD is separated into two subcategories followingRead MoreAlzheimer s Disease ( Ad )1172 Words   |  5 PagesAlzheimer’s disease (AD) is a disorder that is characterized by degeneration of the hippocampal and cortical neurons of the brain – causing memory impairment and a decline in cognitive abilities. The current study by Ghoneim et al.1 focuses on the role of three proteins in the pathogenesis of Alzheimer’s. Brain derived neurotrophic factor (BDNF) signaling is important for development and maintenance of normal neuronal circuits in the brain. Glial fibrillary acidic protein (GFAP) is expressed by astrocytesRead MoreAlzheimer s Disease ( Ad )1361 Words   |  6 PagesAlzheimer’s disease (AD), according to Shan (2013), â€Å"is the most common form of dementia. It is a degenerative, incurable, and terminal disease.† (p. 32). AD is a disease in which the brain essentially deteriorates, is vastly progressive, and complex. Because there is no cure for this disease, scientists and researchers should continue seeking effective prevention measures. Alzheimer’s disease accounts for hundreds of thousands of geriatric deaths each year, and affects not only the patient, butRead MoreAlzheimer s Disease ( Ad ) Essay1588 Words   |  7 Pages This paper explores various elements and issues related to Alzheimer’s disease (AD). Topics briefly detailed include etiology, symptomology, diagnosis, neuroanatomy, neurotransmitter systems involved and treatments that focus on neurotransmitters. Emphasis is placed on such topics as cognitive decline and dementia; neurological change; and changes to neurotransmitters and synapses. Details concerning diagnosis and treatment are brief, but do elaborate somewhat on present studies into addressingRead MoreAlzheimer s Disease ( Ad )1067 Words   |  5 Pageswith Alzheimer’s disease (AD). Alzheimer’s disease (AD) is a brain disease that slowly eradicates recollection, thinking skills and slowly the ability to perform menial tasks. Alzheimer’s disease is classified as the loss of cognitive functioning-thinking, remembering, and reasoning- and behavioral abilities to such an extent that it interferes with a person’s daily life and activities. (****1*) Dementia can vary depending on the types of brain changes such as Lewy body disease, (which are abnormalities